> We have penicilin that works against all human cells.
Penicillin works against bacteria, in particular gram-positive bacteria; to a lesser extent gram-negative bacteria too (this depends on the cell membrane structure of bacteria; there are other penicillin derivatives that are also more effective on gram-negative bacteria than penicillin is, but by and large the main target will be gram-positive bacteria). It does not work against human cells. If your comparison is about drugs in general, then of course cytotoxic drugs will have an effect; simplest example I can remember off-hand is colchicin. Of course it should work against cancer cells and non-cancer cells, unless there are some mutations where colchicin could no longer bind to, but that seems very very rare, due to the natural target of colchicin involved in cellular division.
It was an analogy. Just like penicillin kills a broad variety of bacteria we also know substances that kill a broad variety of cancer cells. Arsenic, for instance, and shotgun bullets. The problem is they usually select for all cells or all human cells, not cancer cells more specifically.
Cancer cells, by definition, are not a uniform mass. It will depend on the cancer type, which in turn is defined by the properties those cells have. And mutations happen all the time, often more in cancer cells when their repair systems also have mutations, e. g. are less efficient. By that definition alone, there can never be a wonder-cure for all cancer types. At best you can find some proteins more important (p53 for instance) and while more than 50% of cancer cells have some form of mutation in p53, others simply don't. By that definition there will never be a penicillin-equivalent to all cancer types.
But that's not a cure. If they don't take that drug, assuming it works, they still have the original mutation in the cancer cells.
> Patients that take part in clinical trials really are the heroes here.
Are they?
To me personally, putting people into a permanent state of requiring drugs to survive, is not really cure. It's just maximizing income for those selling those drugs. And none of those drugs work exceedingly well; people still die, even if to other disease or frailties. I don't understand this hype in general.
I can understand being frustrated and cynical with the pharmaceutical industry, but I have never worked with a single doctor that approaches patient care with the goal of getting them "hooked" on something for life.
The pharmaceutical companies are not the ones making clinical decisions - in this case, it's a shared medical decision between a patient and their oncologist.
Having seen how horrific pancreatic cancer is, how difficult it is to treat, and the decades of slow research done by academic scientists to get to this point, I am elated that we have a tool to give patients more time with their families even if their cancer can't be "cured" with this particular drug.
This may seem unsatisfying, but it's real, measurable progress. KRAS has been known about since the earliest days of cancer research, so it's a true breakthrough to finally have a drug targeting it.
Wow, this is such a wildly pessimistic and cynical take. Are you okay?
> But that's not a cure. If they don't take that drug, assuming it works, they still have the original mutation in the cancer cells.
The person you're replying to called this out specifically:
> and also various combinations with other drugs.
Why do you think they try it in combination with other drugs? You might be right that this drug alone might not be a cure, but if it inhibits cancer growth, then it empowers other drugs to work more effectively.
> people still die
So what... We do nothing, then? This is your complaint? That we can't be immortal, so why bother trying to cure anything?
>However, even though the overall number of cases rises as the population grows, fewer people are getting and dying from cancer. Between 2000 and 2021, the incidence rate — or the rate of new cancer cases per 100,000 people — declined by 5.7%, while the annual mortality rate fell by 27.5%.
Cancer is a broad term encompassing many sorts of malfunction and nearly 40% of Americans will be diagnosed with it at some point because if you survive other hazards and maladies cancer is often what gets you.
To me it does not matter whether AI is open source or not. Yes,
it is better if it is open source, no doubt, but either way I
think AI must die. Naturally it won't, we all know that, but
this does not change my statement in the slightest - AI must
die. Having it open source is, while an improvement, just
painting lipstick on the pig.
While this makes Arch Linux look bad right now, I recall how many years ago Gentoo was leading the pack with regards to having many clever people on board. Then came Arch Linux and eventually it put Gentoo as a second tier distribution. Arch has a lot of momentum; I myself am using Manjaro right now, primarily because it makes many things - including compiling from source - simple. As simple as Slackware, before Slackware fossilized (it's still alive of course, but just look at the most recent ISO release, then you'll understand the problem; when a distribution is no longer able to release .iso files, then it is in my book dead).
Is the USA finally doing something about foreign lobbyists here? Trump is like the ultimate tool here for foreigners to gain influence, no matter the country. Yuri explained this already in the 1980s (!!!): https://www.youtube.com/watch?v=9apDnRRSOCk (it's the KGB view, so biased too, of course, but if you extend it, then also connect it to Epstein, you have basically undermined democracy effectively; a shame Yuri is dead, he would have had a field day with "analysing" Putin).
OP is talking about American's here. AIPAC is made of and paid for AIPAC, like other political packs or other American groups. AIPAC is just Americans, doing the American political thing.
I have finally realised that the year of true WebAssembly breakthrough will coincide with Desktop Linux of the year and GNU Hurd installed on every toaster. It will be a strange year ...
There are more and more posts coming up recently about AI being problematic. But people use it. It's strange. It's like hitting yourself with a hammer on the head, wondering why that hurts but you keep on doing it.
I like it.
The USA is like the Wild Wild West. No wonder Al Capone could prosper.
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