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bentt · 2026-04-26T04:55:52 1777179352

Big Pharma refuses to believe that the gut microbiome plays a significant role in human health. They either don't take it seriously or think it's so complex that it's not worth working on. I think they're totally wrong and that the microbiome is the arbiter of not only Alzheimers but cancer and other metabolic disorders like T2 Diabetes.

coderintherye · 2026-04-26T05:39:18 1777181958

Regardless of what you believe, the idea that big pharma doesn't believe in gut microbiome playing a significant role in human health is absolutely wrong as easily seen by the rise of GLP-1 drugs (which affect gut microbiome) and are the blockbuster drugs "big pharma" is investing heavily in currently. Perhaps, go take a look at that.

bentt · 2026-04-27T02:57:18 1777258638

GLP-1’s are a weak counterpoint. Perhaps go take a look at that yourself.

bentt · 2026-04-25T02:43:33 1777085013

I hate this and I hate that they think it's what they should be doing.

If Google can't see the difference between this and useful, moral AI tools then I worry for their path forward.

bentt · 2026-04-16T04:52:36 1776315156

I thought this was Apple’s plan all along. How is this not already their thing?

bentt · 2026-04-16T01:17:17 1776302237

great tip! i didnt know this.

bentt · 2026-04-16T01:16:00 1776302160

The only reason they would do this is because some kind of research determined it would yield higher revenue.

bentt · 2026-04-09T04:42:09 1775709729

It does blow my mind that advertisers pay to show ads and I pay to not show ads.

That my friends is a Business Model.

bentt · 2026-04-07T08:55:33 1775552133

https://www.campop.geog.cam.ac.uk/blog/2024/09/19/childbirth...

Childbirth was extraordinaly dangerous. 6-8 births per woman and a 1-2% chance of dying per birth for the majority of history.

We have no idea what that was like. Rates today are ~0.013%.

bentt · 2026-04-03T12:15:54 1775218554

I’m a little confused. So you got a VPS… was that just to host the result? Surely you weren’t running the models on it?

What were the models running on? It doesn’t matter a ton but would help paint the whole picture better.

a96 · 2026-04-04T13:43:27 1775310207

Also no mention of quants and not even sizes in many cases. I wish someone did this kind of comparison well.

polski-g · 2026-04-05T13:05:21 1775394321

Opencode doesn't publish what quantization they offer.

bentt · 2026-04-02T20:14:39 1775160879

I’m a Cursor user but I am not an agent maximalist. I just like having it work on code in an IDE with good inline diffs and a nice chat UI.

This change is possibly too big and unless all my existing usage patterns are maintained or improved, I’ll likely give CC a try now. Not optimistic.

all2 · 2026-04-02T20:25:04 1775161504

If you're in the market, OpenCode is quite good and has become my daily driver. You may also consider pi[0], but that's (from what I've heard) more agenty.

[0] https://shittycodingagent.ai/

zenoprax · 2026-04-02T22:32:09 1775169129

I only used Cursor in short bursts so 20 USD per month was hard to justify. I recently switched to VSCodium + Cline + OpenRouter and I can use any model I want (currently Step 3.5 Flash for "Temu Sonnet"). It scratches the itch very well for me for literal pennies on the dollar.

I should also add: Cline doesn't require any account at all. I just installed the extension and added my OpenRouter API key and that was it.

bentt · 2026-04-02T20:10:53 1775160653

Yep, Composer 2 has been quite good for me too. I only turn to Opus for major brainteasers.